DNP - My Experiment with Dosage WHOA!

[littlerunt]

To recap, I've been on 400mg/day for five days. 5'8", 170lb, 11-12%BF.

Sides at 400mg/day were *kinda* manageable: slight sweating, small rashes on ears, elbows, chest, chronic headaches, feeling slow. I did feel it working, but very lowkey.

Point is: Yesterday I upped my dosage to 600mg/day - BIG F*CKING MISTAKE. I underestimated the compounding effects and I REALLY regret it. When I took my third 200mg pill (yesterday evening at 11pm right before bed), within two hours my entire body from hairline to big toe was COVERED in the worst, itchiest, most swollen looking rash you can imagine - I doubled my Benedryl dosage to absolutely no avail. I even took pictures of the rash because it looked so bad, but have decided (I promise, you'll thank me) to NOT post them!

Then after an hour of being in itchy swollen HELL, my heart rate jumped up, breathing became shallow, my lungs started to wheeze, and my chest tightened up like someone screwed a c-clamp around it. Not kidding. I somehow managed to ride it out, although I didn't sleep a wink and the whole thing made me want to explode from all the anxiety.

Benedryl finally took away the rash at about 7am this morning, and I was able to sleep at last. Lesson learned the hard way, I guess. I'm taking today off from the pills, and will stay on the 400mg/day dosage from Monday to Friday. Total, it will be a 14 day cycle with the average per day dosage being 400mg/day. Anyhow, OhHannah gave me some nice research info, so here it is for everyone if they want it: DNP - Up the Dosage?

[onemuscledbeagle]

Well it looks as though you found your therapeutic window at 400 mg daily. Sorry to hear you had such a reaction. Thus far, for me, I am at 600 mg total daily and have no side effects however, I am 243. My understanding of DNP is the recommendation is based on weight 2-6 mg/kg of body weight to total daily use. Please correct me if I am wrong. Keep the benedryl handy and make sure you are drinking plenty of water.
OMB

[littlerunt]

Definitely going to up my H2O intake - was slacking off. And Benedryl is saving the day, to be sure. Taking a break today, but tomorrrow will do 200mg at 8am, then 200mg at around 8pm. That's probably a good way to break up the 400mg total. Definitely NOT trying the 600mg again!

Originally Posted by onemuscledbeagle

Well it looks as though you found your therapeutic window at 400 mg daily. Sorry to hear you had such a reaction. Thus far, for me, I am at 600 mg total daily and have no side effects however, I am 243. My understanding of DNP is the recommendation is based on weight 2-6 mg/kg of body weight to total daily use. Please correct me if I am wrong. Keep the benedryl handy and make sure you are drinking plenty of water.
OMB

[ORBIS]

Glad your ok, But for anybody reading this please dont "ride it out" if you think you may have took to much. See a doctor fast! Shit can kill you.

[meowmeow]

You should be taking Benedryl every night before bed for the entire cycle...even if you have no rash...the anti-histamine should prevent rashes from occuring.

[getthepump40]

dang man glad to hear you made it through, don't mess with that it's really dangerous.....and thanks for not posting those rash pics

[littlerunt]

Okay, read below for how I tried to solve my problem of figuring out what dosage was correct for me (sorry to those of you that saw this post elsewhere)...

I ended up making a per day half-life spreadsheet for myself factoring in the compound effect of the drug, and it was a REAL eye opener. I factored in a three-day half life for each dose I have taken over the last five days, and it looks like last night, when things got pretty bad, I had, most likely, the equivalent of just over 1400mg in my system when I accounted for the compound effects over the last five days. No wonder I almost went nuts! I worked backwards in the spreadsheet and deduced that my body can *handle* (meaning no chest pain, no shallowness of breath, and only a somewhat annoying rash) the equivalent of about 1000mg tops in my system at any point. Remember, that doesn't mean I'll take 1000mg/day - it means that I factor in what's already in my system before I dose myself each day. Turns out for the last half of my cycle I'll need to take 400mg/day only once more, and I can keep the remaining days at 200mg. That STILL keeps my blood levels of DNP slightly over 1000mg through next Monday. LESSON LEARNED. (Sorry if this sounds confusing)...LittleRunt

[Dinitro]

Out of curiosity, are you using mine or someone else's?

[OhHannah]

Originally Posted by ORBIS

Glad your ok, But for anybody reading this please dont "ride it out" if you think you may have took to much. See a doctor fast! Shit can kill you.

Well, the really fucked up part is there's a limit to what a doctor could do to keep you alive if you OD on this particular substance. There is not a terribly good antagonist or reversal agent for this drug. They can put you on oxygen and fluids and ice packs and give you ascorbic acid - that's Vitamin C. That's pretty much all they can do; they can't actually fix or reverse what the DNP did to your body's cells.

DNP poisoning is managed in a clinical setting with supportive care, which means physical temperature control (ice packs, etc), oxygen and fluid replacement. Salicylates (aspirins) are NOT used as they are considered both ineffective and potentially deadly as they also have an uncoupling effect on oxidative phosphorylation. Other antipyretics are considered ineffective due to the peripherally mediated mechanism of action in DNP-induced hyperthermia, and should not be used in any case due to potentially fatal drug interactions. Eg, don't take Tylenol and double especially don't take aspirin to reduce a DNP fever.

[Blood1]

Have this be a lesson for everyone. DNP isn't for shits and giggles. Use it safely.