anyone hear of this

[Opus]

Recombinant Human Keratinocyte Growth Factor-1 (KGF-1)

Alternate names: KGF1, KGF-1, FGF7, FGF-7, HBGF7, Fibroblast growth factor-7

does it have purpose

[intensity77]

helps with tissue repair, works thru the small intestines..

[bm2006]

this is the first time i ever heard of it

[KingGuss]

Originally Posted by Opus

Recombinant Human Keratinocyte Growth Factor-1 (KGF-1)

Alternate names: KGF1, KGF-1, FGF7, FGF-7, HBGF7, Fibroblast growth factor-7

does it have purpose

Bump, sounds interesting.

[awakened615]

It seems as though KGF-1 has not much to do with muscle repair at all. It does however help with the repair of your skin. Your whole entire body's surface is covered with epithelial tissue. This tissue when damaged by what I have found uses the KGF-1 to help with the proliferation of epithelial cells. As we know when our muscles are damaged our cells repair them. Same situation as for everything in our body obviously too. It seems however that KGF-1/2 don't seem to have anything to do with our muscle repair. There are other studies done on mice and rats but I can only read and comprehend so much. I got a little info from the journal of preiodontal research. Here ya go:



Objectives: Keratinocyte growth factor-1 (KGF-1) is up-regulated in chronic inflammation and specifically stimulates epithelial cell proliferation by signaling through the epithelial-specific keratinocyte growth factor receptor (KGFR). We examined KGF-1 and KGFR protein and gene expression in healthy and diseased periodontal tissues.

Methods: Tissues were collected from patients with periodontal health or disease, immediately frozen and stained for KGF-1 and KGFR protein expression. Laser capture microdissection of epithelial and connective tissue cells with reverse transcription–polymerase chain reaction (RT–PCR) examined KGF-1 and KGFR gene expression profiles and enzymatic digestion with heparitinase, chondroitinase ABC or pre-treatment with suramin examined epithelial surface molecule interactions with KGF-1.

Results: In tissues collected from healthy patients, KGF-1 protein localized to areas of junctional and basal oral epithelial cells and was significantly increased in periodontal pocket epithelium (p < 0.01) and in the oral epithelium (p < 0.05) of disease-associated tissues. KGFR localized to the junctional and the parabasal cells of oral epithelium, with the relative staining intensity being increased in disease-associated pocket epithelium (p < 0.05). Laser capture microdissection with RT–PCR confirmed KGF-1 and KGFR were specifically expressed by connective tissue and epithelium, respectively. KGF-1 localization to epithelial cells was largely eliminated by suramin pre-treatment, indicating interaction with the KGFR.

Conclusions: KGF-1 and KGFR proteins are expressed in healthy periodontal tissues but significantly increased in diseased periodontal tissues. We hypothesize up-regulation of KGF-1 and KGFR protein associated with disease regulates epithelial cell behavior associated with onset and progression of periodontal pocket formation.

[cutlersosa]

this stuff looks very interesting.

i wouldnt give it a go though. tried and true for me.

[funbos]

looks interesting