B-12

[IFIWAS]

Neve used injectable b-12 purely for its own results..a few years ago I used osme to cut some Prop but that was it.

Which B-12 should I use...how much, and when.

Thanks fellas

[Born2Juice4Ever]

Nutrition Fact Sheet: Vitamin B12


Physiological Functions

Vitamin B12 is required for folate absorption, storage and activation to its coenzyme forms. Thus vitamin B12 works in tandem with folate to support cellular replication and a deficiency in either vitamin can adversely affect the functions of both. The only unique role identified for the vitamin is the synthesis of myelin a constituent of the sheaths that protect nerve fibers. Neurological damage associated with a vitamin B12 deficiency can occur in spite of adequate folate intake.

Factors Affecting Availability

Vitamin B12 is generally stable and is minimally destroyed with normal methods of cooking and processing. However, up to a third of this vitamin can be destroyed if cooking time is prolonged.

Vitamin B12 is absorbed by both passive and facilitated diffusion. Only small amounts of the vitamin are passively absorbed so for optimal absorption, facilitated diffusion involving binding to intrinsic factor is required. Intrinsic factor, produced by gastric mucosa, promotes vitamin B12 absorption in the ileum. Gastric acidity also promotes availability of vitamin B12 by releasing it from the polypeptides to which it is bound in food sources. Decreased gastric acidity due to medications or age can significantly compromise vitamin B12 status.


Deficiency

Vitamin B12 deficiency is most commonly the result of inadequate absorption. Low intake can also contribute since vitamin B12 is exclusively found in foods of animal origin.

Megloblastic anemia is a clinical manifestation of vitamin B12 deficiency which reflects the dependence between folic acid and vitamin B12. Megaloblastic anemia caused by inadequate production of intrinsic factor is designated pernicious anemia. Neurological symptoms associated with vitamin B12 deficiency include progressive neuropathy with demyelination of the peripheral nerves advancing to the central nervous system. Numbness and tingling in the hands and feet, stiffness and weakness in the legs, and an unsteady gait are often observed. In the elderly, vitamin B12 deficiency is characterized by mental disorientation, memory loss, and a yellowish tint to the skin due to concurrent anemia and jaundice.

The dependence of folate metabolism on vitamin B12 can be bypassed by high dose folate supplements which will reverse the hematological changes, but not the neurological damage. To prevent the progressive irreversible neurological damage of undetected vitamin B12 deficiency, nonprescription folate supplements cannot exceed 400 mcg.

Toxicity

Vitamin B12 is not toxic in oral doses up to 100 mcg daily because absorptive efficiency decreases with increased dose.

The upper limit of safety for vitamin B12 has not been determined due to lack of data substantiating adverse effects at high intakes. The Food and Nutrition Board of the Institute of Medicine recommends that vitamin B12 should be consumed only from food sources to prevent intake of potentially toxic levels.
Here is the source of this VALUABLE information:
http://www.feinberg.northwestern.edu...tamin-b12.html



B2J4E

BTW: I have more information on b12 since I find that it is an extremelly valuable compound. Just let me know if you want more.

[IFIWAS]

So should we do the injectable or just take an OTC B-12 supplement Vitamin?
Both do the same I suppose?

Aside from the normal effects, as I remember, and read, it made me alittle more vascular the last time I took it...a great side effect if you ask me.

Increase in red blood cells correct?