Faslodex Anti E injection

[Opus]

How FASLODEX works

Hormone receptor-positive breast cancer is a type of breast cancer in which cells need the hormone estrogen to grow. In this type of cancer, estrogen is delivered into the breast cancer cells by message-carrying proteins called estrogen receptors.

Given by intramuscular (IM) injection once a month, FASLODEX works by binding to estrogen receptors, which blocks estrogen from binding. FASLODEX causes the estrogen receptor to change shape and not work as well. In addition, FASLODEX causes a decrease (downregulation) in the number of estrogen receptors. This may interfere with cancer cell activity, which, in part, may slow the growth of the breast cancer.

In clinical trials, FASLODEX was found to be effective when tamoxifen no longer worked.

How does Faslodex® work?

* Oestrogen is a female sex hormone (natural chemical produced by the body) that is known to be able to encourage the growth of some types of breast cancer cells.

* Faslodex stops the action of oestrogen by preventing it from attaching itself (binding) to sites (called receptors) on cancer cells.

* Faslodex also causes a decrease, or downregulation, in oestrogen receptor concentration and causes the receptors to change shape and become less functional; without functioning oestrogen receptors, oestrogen cannot signal the breast cancer cell to grow.

* By stopping the actions of oestrogen, Faslodex is useful in slowing the growth of the tumour and may cause it to shrink.