Cabergoline (Dostinex, Cabaser)

[EgoPrimo]

Cabergoline (brand names Dostinex® and Cabaser®), an ergot-derivative, is a potent dopamine receptor agonist on D2-Receptors. It also acts on dopamine-receptors in lactophilic hypothalamus cells and causes thereby a suppression of the prolactin-production in pituitary gland.

Pharmacokinetics
Following an oral single dose the drug is resorbed within 0.5 to 4 hours from the GI-Tract with considerable interindividual differences. Meals do not alter the absorption characteristic. Human bioavailibility was not determined, because the drug is intended for oral use only. In mice and rats the absolute bioavailability was 30 and 63%, respectively. Cabergoline is rapidly and to a great extend metabolized in the liver and excreted in bile and far less in urine. All metabolites are less active than the parental drug or inactive. The human elimination halflife is estimated to be 63 to 68 hours in patients with M. Parkinson and 79 to 115 hours in patients with pituitary tumors.

Carcinogenity
In rodents a dose dependent increase in malignant tumors has been found. They are thought to be species-specific. No clinical data exists on carcinogenity in humans.

Off-Label/Recreational Uses
It has at times been used as an adjunct to SSRI antidepressants as there is some evidence that it counteracts certain side effects of those drugs such as reduced libido and anorgasmia. It also has been suggested online that it has a possible recreational use in reducing or eliminating the male refractory period.

Side effects
Approximately 200 patients with newly diagnostizised M. Parkinson participated in a clinical study regarding the monotherapy with cabergoline. Seventynine (79) % reported at least one side effect. These side effects were chiefly mild or moderate:

GI-Tract: Side effects were extremly frequent. Fiftythree Per Cent of patients reported side effects. Nausea (30%), obstipation (22%), and dry mouth (10%) were very frequent. Frequent were gastric irritation (7%), vomiting (5%), and dyspepsia (2%).

Psychiatric Disturbances and CNS: Altogether 51% of patients were affected. Very frequent were disturbances of sleep (somnolence 18%, insomnia 11%), vertigo (27%), and depression (13%). Frequent were dyskinesia (4%) and hallucinations (4%).

Cardiovascular: Approximately 30% of patients experienced side effects. Most frequent were hypotension (10%), peripheral edema (14%) and non-specific edema (2%). Arrhythmias were encountered in 4.8%, palpitations in 4.3%, and angina pectoris in 1.4%.

In a combination study with 2,000 patients also treated with levodopa the incidence and severity of side effects was comparable to monotherapy. Encountered side effects required a termination of cabergoline treatment in 15% of patients. Additional side effects were infrequent cases of hematological side effects, and an occasional increase in liver enzymes or serum creatinine without signs or symptoms.

As with other ergot-derivatives pleuritis, exsudative pleura disease, pleura fibrosis, lung fibrosis, and pericarditis are seen. These side effects are noted in less than 2% of patients. They require immediate termination of treatment. Clinical improvement and normalization of X-Ray findings are normally seen soon after cabergoline withdrawal.

The reported incidence and severity of side effects in hyperprolactinemic patients was comparable.

Comments
Male 58yrs old using 10 months,
REASON: Mild prolactinoma or microadenoma
SIDES: Possibly slightly constipating; none other than that.
COMMENTS: Lowered prolactin markedly; increased testosterone to low end of normal zone; greatly improved libido (like second honeymoon!); lost 12 pounds I needed to lose. Needed this 10 years ago; amazing.

Male 36yrs old using 6 years
REASON: Prolactinoma
SIDES: I can't say for sure any of my issues are from the meds. I do seem to get confused once in a while, sometimes a bit angry, pimples on my back, but not really bad acne. I would say my memory isn't too good if I am not interested in it and it is hard for me to concentrate sometimes.
COMMENTS: Even if all the issues above were from dostinex, I can't say I would complain. The breast milk and no sex drive i had before taking it were worse than anything I feel now.

Male 51yrs old using 14 months
REASON: Hi prolactin, lo testosterone
SIDES: Just a headache after taking ( only take once per week) for a few weeks, no headaches nor side effects in months
COMMENTS: Was very good for me, depression and anxiety attacks practically gone, sex drive up, energy levels and muscle tone better. Wish I had this years ago.

Male 39yrs old using 30 days
REASON: prolactinom
SIDES: nausea, waitloss
COMMENTS: sex drive is back !!!!!!!!!!! in full force

Male 49 yrs old using 5 months
REASON: piturtary tummor
SIDES: started out ok taking only a half a pill twice a week. now after taking 1 1/2 pills twice a week and on it for 5 months it is making me a mad man.But i now that it is working because the test come back showing it is lowing the prolactin. i am not sure if i can hold out i may have to change the drug.
COMMENTS: i will need to talk to my doctor after reading some of the other side effects and comments.Its about to destroy my life also.

Male 41yrs old using 2.5 years
REASON: pituitary tumor
SIDES: Made me a terrible psycho. Have to seek psychitric treatment. Severe depression, complete personality change.
COMMENTS: It did lowere prolactin level. But side effect is very scary and made me a different person and destroyed my life and carrer.

Male 45yrs old using 18 months
REASON: pituitary tumor
SIDES: Made me a complete psycho. Sex drive sky high and uncontrolable anger and actions. Very agressive, paranoid, and jealous. Very near distroyed my life.
COMMENTS: If your endocrinologist says it is not the medicine, then get a secon opinion!!!! This is an ergot dirivative. The same stuff they make LSD from.

[tiggerizme]

Good post Ego.. Where did you find this??

[EgoPrimo]

Ergot is a fungus that lives on rye and other grasses and is pathogenic to its host as well as to humans and other animals that ingest it. Ergot is also a great source for the art of healing and the pharmaceutical industry.

Like most great pharmacological resources, ergot is a powerful poison. More specifically, many ergot alkaloids have a poisonous effect on the central nervous system, interfering heavily with neurotransmitter function. And here also lies the great promise of ergot as medicine.

Ergot is an old member of the materia medica. It has been used in traditional medicine and it has been scientifically studied for more than 50 years. Among those studying ergot and its derivatives was the Swiss chemist Albert Hofman whose experiments let to the discovery of LSD, an ergot derivative that strongly interferes with the neurotransmitter serotonin.

In the field of conventional medicine, ergot derivatives are nowadays mostly used for their potential to enhance another neurotransmitter, dopamine. A dopamine deficiency is a common grave medical condition, Parkinson's Disease.

While the ergot derivative LSD is used almost exclusively as recreational drug with practically no use in conventional medicine, dopamine enhancing ergot derivatives are sold in pharmacies around the world. The most common ergot prescription drug is probably Sandoz' Parlodel (bromocriptine by generic name). Even though it's very much a conventional medication, bromocriptine and other dopamine enhancing ergot derivatives have a clear potential as life-style drugs. Not all, but many ergot-based medications for Parkinson’s Disease have a profound sexuality enhancing (side) effect.

All dopamine-enhancing medications can be used in the treatment of Parkinson’s Disease, but not each and every dopamine enhancement produces pro-sexual (side) effects. On a similar level, while many medications used for serotonin enhancement (in the treatment of clinical depression) have anti-sexual effect, this anti-sexual effect is not an unavoidable side effect of serotonin enhancement.

The answer to the puzzle lies in dopamine and serotonin receptor sites. Not all dopamines and all serotonins are alike. The effect of some dopamine binding to specific sites is pro-sexual, and the binding of some other dopamines to other sites may be neutral at best, or even anti-sexual. The same holds true for serotonin enhancing drugs and serotonin binding sites.

Until now, many ergot derivatives are considered "dirty" drug. They are named like this because their action is not all too specific. They have the therapeutic effect for which they are prescribed, but they have many other effects, too. From the perspective of conventional medicine, the pro-sexual effects are a side effect.

[apexx]

Good info bor

[EgoPrimo]

Anyone on here have experience with this?

[Bammy]

I used it to reduce tren lactation. At first it was working great, did what it was supposed to do. An additional side effect was high sex drive, really high. I am usually a pretty shy person and I actaully got really active and serious about hunting down girls like my life depended on it (and I am not single, this is something I don't ever do).

There were also mood swings, like at one point I would be ecstatic, then get very depressed later.

Another thing is that the stuff made me increasingly more and more sick. It stared out as nautia in the mornings after the first week, that would last for about a half hour. Then it got progressively worse until I was nautious as shit for 3/4 of the day. I felt light headed like I needed to eat more, but eating made me really sick as well. I actaully lost weight on my test/tren cycle due to feeling like this. I finally stopped it about 5 or 6 days ago and I'm starting to feel better.

But I think I may have been taking too much. I started at 500mg EOD, then went down to 500mg E3D, and the n to 375mg E3D. Reading the half life, I think it was all building up in my system, and it really messed me up.

[krzna]

I dont want to elaborate what exactly happenned to me when i was using dostinex. I kinda regretted it. My drive was on the ROOF!
test 1g/tren 400/cab/yohimbe

I will use it into my PCT. And no I am not shy like my good man bammy here and I kinda became an asshole. Bammy kinda knows, so do a few others.

However I love this drug.... words can't express how I felt on it. I've never felt more confident about myself EVER. The drop down swing I started to experience only after a week. How abt you Bammy? It took me 4 days to kick in I was on 375 ed. Day 14 i was havin sex like 8 x plus jerkin off almost water. Not to mention my spunk was STINKIN ... ewww

[Bammy]

Yeah K, I did feel more confident, until i started getting sick, then I couldn't really feel good about anything. It gave me mood swings so i would feel super confident one day, then depressed the next. Caber had some very good and very bad effects, but the bad outweighed the good by far.

[Scheizekopf]

Originally Posted by Bammy

Yeah K, I did feel more confident, until i started getting sick, then I couldn't really feel good about anything. It gave me mood swings so i would feel super confident one day, then depressed the next. Caber had some very good and very bad effects, but the bad outweighed the good by far.

How's it going Bammy?

How your's cycle goin?

[K-Man]

Great info, I use it-but had no idea of all its properties...
Thanks EG...
K-Man