Yohimbine

[Scheizekopf]

Yohimbine



Systematic Name: 17α-hydroxy-yohimban-16α-carboxylic acid methyl ester

Identifiers
CAS Number: 146-48-5
ATC Code: G04BE04

Chemical Data
Formula: C21 H26 N2 O3
Mol. Weight: 354.44 g/mol (base) // 390.90 g/mol (hydrochloride)


Yohimbine is a selective competitive alpha2-adrenergic receptor antagonist and is used for treating erectile dysfunction. It is claimed to be an aphrodisiac. It is also used as a weight loss supplement as it increases noradrenaline (norepinephrine) levels.

Common Uses: Used in tablet, capsule, and tincture form for increased serum testosterone levels, muscle growth and strength, weight loss, fatigue and sexual function. Research shows it is a vasodilator, which means that it increases blood flow to the extremities and appendages. It does this via an indirect mechanism of increasing the release of noradrenaline. Yohimbine also has been shown to decrease fat synthesis in the body by increasing fatty acid mobilization (causing weight loss).

Common or Recommended Dosages: 10 to 20 mg/day divided into three dosages. One tablet (5.4mg) three-times/day for fatigue.

Potential Side Effects: Yohimbine ingestion (4mg to 20 mg) has been associated with side effects including nervousness, insomnia, anxiety, urinary frequency, dizziness, tremors, headache, tachycardia, hypotension, hypertension, nausea and vomiting, brochospasm and lupus-like syndrome. Higher doses of oral Yohimbine create numerous side effects such as rapid heart rate, high blood pressure, and overstimulation. Yohimbine is also used clinically to produce anxiety.

Food-Drug/ Drug-Drug Interactions: Drugs such as phenothiazines enhance Yohimbine toxicity. Tyramine containing foods and nasal decongestants or diet products containing phenylpropaanolamine should be avoided to prevent a hypertensive crisis.



References:
Yohimbine: Accidental Discovery As Fatigue Treatment. Aids Treatment News, John S. James, 18 September 1992.
The Health Professional’s Guide to Popular Dietary Supplements. Allison Sarubin, MS, RD
Wikipedia: Yohimbine

[Scheizekopf]

Today is my first time trying it.

This morning I used 2.5mg/200mg Y/C.

Later I'll try 5mg/200mg Y/C.

[Scheizekopf]

Yohimbine vs. Yohimbe

Originally Posted by 1Fast400

"Quite a bit of confusion seems to exist about the difference between Yohimbine and yohimbe. Yohimbine is simply the principal alkaloid from the herb P. yohimbe. However, there are 31 other yohimbane alkaloids that can be present in herbal yohimbe preparations. Some of these have different and unknown selectivities and potencies (and thus, effects) at the adrenergic receptors -- in addition, these preparations vary greatly from brand to brand and even from batch to batch, as no standardization for extraction exists. In fact, a recent investigation found that most over the counter preparations have little to no actual yohimbine. And, even in the more potent preparations, most find a higher degree of undesirable effects with the herb vs. pure Yohimbine Hydrochloride"

Originally Posted by Steroidology.com

Dosing of Yohimbine HCL: 10mgs per 100lbs or (0.2mg/kg of bodyweight) other yohimbe/herbal formulas vary

Side Effects: dizziness, anxiety, skin flushing, headaches, hyperstimulation and nausea.. Smurftastic! Most common and most important to monitor: rapid increase in heart rate during cardiovascular activity

***Best to be taken first thing in the morning on an empty stomach. Here is smurfily why: The lipid-mobilizing effects of yohimbine are completely negated when administered with or after a meal. Yohimbine increases insulin secretion during glucose stimulation (a meal). Yohimbine when takin with a meal, causes increased insulin secretion which blunts its lipid mobilizing effects. However, in fasting conditions, yohimbine does not increase insulin levels. These results demonstrate the importance of nutritional status when administering 2-antagonists as lipid-mobilizing agents. Yohimbine administration first thing in the morning on an empty stomach could be followed in two to three hours by ingestion of a high-protein, high-fat meal. At least this is the MOST optimal way to utilize yohimbine.

If a yohimbe product has a 2% extraction. Such as Yohimbe 1111. It has 1111mg of Yohimbe and 22.22mg of Yohimbine.

[bgptbull81]

ya i was on this for some time and it really ups you're sex drive.....its like a marathon........never ends

also helped burn some stub fat.

[quitman]

hey can any knowledgable members recommend a good fat burner

[bgptbull81]

ya venom bro..cant beat it...