T4

[RELENTLESS]

Bros,

fixing to start some of IBE's T4, was wondering about what kind of dosage i should run with it? I am taking it to work synergistically with GH but i am not sure how much i need to take. thanks

RELENTLESS

[Scheizekopf]

Couldnt find much on dosing.

Here's a wikipedia link with some info but not dosing info.
http://en.wikipedia.org/wiki/Thyroxine

[Scheizekopf]

Eur J Pediatr. 1997 Feb;156(2):94-8. Related Articles, Links

A thyroxine dosage of 8 micrograms/kg per day is appropriate for the initial treatment of the majority of infants with congenital hypothyroidism.

Touati G, Leger J, Toublanc JE, Farriaux JP, Stuckens C, Ponte C, David M, Rochiccioli P, Porquet D, Czernichow P.

Hopital Saint-Vincent de Paul, Paris, France.

The adequate L-thyroxine dosage for the initial treatment of infants with congenital hypothyroidism is a subject of controversy. Some recommend higher dosages (> 10 micrograms/kg/day) to ensure adequate levels, while others advocate lower dosages to permit normalisation of thyroid status. The aim of this study was to evaluate the results of a treatment strategy using an initial dosage of 7.5-8.0 micrograms/kg per day, TSH measurements being taken at 15 and 30 days of treatment. Fifty one newborns infants with primary congenital hypothyroidism detected by neonatal screening were treated with the same therapeutic strategy. A mean L-thyroxine dosage of 7.9 micrograms/kg per day at the onset of treatment and 6.6 micrograms/kg/d at 2 months, normalised the FT4 and FT3 levels at 15 days in 100% and TSH levels at 2 months in 90% of cases. Many patients showed elevated levels of FT4 and a systematic higher initial dosage could expose many infants to a dangerous hyperthyroidism. Patients with abnormal TSH levels at 2 months already had higher TSH levels in the first 8 weeks of life and, despite higher L-thyroxine dosage, also exhibited lower FT4 and FT3 levels. These patients who needed an early increase in dosage had already shown a more profound ante and neonatal hypothyroidism. This subgroup of patients require a higher dosage of thyroxine and early assessment of FT4, FT3 and TSH levels are required for optimum dosage choice. Conclusion: Even though a subgroup of patients may require a higher dosage of L-thyroxine, an initial dosage of 7.5-8.0 micrograms/kg per day, with an early assessment of FT4, FT3, and TSH levels, is adequate for the treatment of the majority of infants with congenital hypothyroidism.

Publication Types:
Clinical Trial

PMID: 9039509 [PubMed - indexed for MEDLINE]

[ajdos]

Originally Posted by RELENTLESS

Bros,

fixing to start some of IBE's T4, was wondering about what kind of dosage i should run with it? I am taking it to work synergistically with GH but i am not sure how much i need to take. thanks

RELENTLESS

I've been usin IBE's as well, I would start at 100mcgs that is close to 25mcgs t3 in equivalance. Work up to 150-200 mcg and pyramid back down.
2wks in and I love the stuff, isn't nearly as catabolic as t3 and with gh it burns fat like hell. Enjoy!!

[RELENTLESS]

THanks for the info Scheizekopf. And ajdos, i will prob stick with what you are recommending. could you perhaps post up what type of pyramid up you used? i heard that with thyroid drugs ya gotta ramp up kinda slow, but i didnt know how to draw that up. thanks again.

[ajdos]

Actually that is true w/ t3...but that is part of the beauty w/ t4, less negative feedback that t3. So in theory you can use t4 for much longer and not have the worry of so much rebound at the end. I was gonna run mine 30 days just the same 10 at 100mcg, 5 at 150, 5 at 200 , and back to 100 for 10. However, I am considering going longer...just a thought at this point. The guy who gave me all the info has done 12 wk cycles and experienced very little thyroid depression and rebound. However to be on the safe side I think I will employ a regular amount of PCT as if I had done t3. Gugguls, and tyramine, some coleous forskoli. That usually gets me back to normal.

[RELENTLESS]

Thanks for the info bro, much appreciated. I guess im gonna give it a whirl starting tomorrow at 100mcg for 5-7 days, up to 150 for about 5, and 200 for about 10 days, down to 150 for about five, etc. hope it will help my GH effectiveness