Benefits of Long term Leydig Supression! STAY ON YEAR 'ROUND

[DanSteelMan]

I finally found a bit of an article I have been searching for. Masscre's year around thread made me look extra hard for it:




Long-term suppression of Leydig cell steroidogenesis prevents Leydig cell aging.

Chen H, Zirkin BR.

Division of Reproductive Biology, Department of Biochemistry, Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.

Male aging is accompanied by reduced testosterone production by the Leydig cells, the testosterone-producing cells of the testis. The mechanism by which this occurs is unknown. Based on the observations that reactive oxygen is capable of damaging components of the steroidogenic pathway and that reactive oxygen is produced during steroidogenesis itself, we hypothesized that long-term suppression of steroidogenesis might inhibit or prevent age-related deficits in Leydig cell testosterone production. To test this, we administered contraceptive doses of testosterone to groups of young (3 months old) and middle-aged (13 months old) Brown Norway rats via Silastic implants to suppress endogenous Leydig cell testosterone production. After 8 months, the implants were removed, which rapidly (days) restores the ability of the previously suppressed Leydig cells to produce testosterone. Two months after removing the implants, when the rats of the two groups were 13 and 23 months of age, respectively, the Leydig cells in both cases were found to produce testosterone at the high levels of young Leydig cells, whereas significantly lower levels were produced by the 23-month-old controls. Thus, by placing the Leydig cells in a state of steroidogenic "hibernation," the reductions in Leydig cell testosterone production that invariably accompany aging did not occur. If hormonal contraception in the human functions the same way, the adverse consequences of reduced testosterone in later life (osteoporosis, reduced muscle mass, reduced libido, mood swings, etc. ) might be delayed or prevented.

PMID: 10611306 [PubMed - indexed for MEDLINE]



Now, This article is stating that your body is onky born with the ability to produce "so much" testosterone. The more you test you produce as a young man, the less you have later on in your late 30's and early 40's....By supressing your own test production by use of steroids, You are keeping your leydig cells from aging, therfore making testosterone production later in life more prominate. They way I understand this research, you can basically hold off your decline in natty testosterone until later in life.....I will look for more info on this....Imagine starting gear at 20 and still be in your prime at 50, lol

post up comments

Another way to look at it is like serotonin...you can only make so much in your lifetime...seems leydig cells are the same way

[DanSteelMan]

If I am mis-understanding, please let me know....

[Massacre]

So you're saying the article is stating that I should supress my own test now so later in life I have more?

[tiggerizme]

I don't understand that one for shit.. LOL.. I'd have to make notes and add and subtract, I'm tired..

[DanSteelMan]

Massacre, Yes...That is what I understand the article to say...Anonymizer will have a better understanding of it....We'll see what he says bud

[hitch]

i do personally know that from staying on for a year that you do keep around 90% off ur gains.
i did it once when i was wanting to compete and found that when i eventually came off , even with normal pct i kept alot more muscle than when compared to my previous 12 week cycles.

but wether or not this would help keep me looking younger and feeling better in my later years is very inconclusive.

know as fertility , i thought i was sterile untill my partner got pregnant several months ago.
no she did not cheat lol , i just assumed that the gear had destroyed my chances, but clearly not

[The Anonymizer]

you hear alot of horror stories...."i stayed on for 2 years straight and now i have to be on testosterone replacement for the rest of my life"....but that just doesnt make sense. thats like saying that a female on birth control from age 15 to 21 will never be able to have kids, and we all know alot of women stay on it longer than that. i think this study is probably pretty accurate...however, i'd like to see what long term effects these long cycles have on the thyroid and pancreas. maybe some, maybe none.

I've noticed the same thing as Hitch also....long cycles prevent the yo-yo effect. This solidifies gains instead of your body basically thinking its going thru a steroid induced fad diet.

[DanSteelMan]

Hitch....I thought I was sterile too...J has polycystic ovaries....and she was on Phenytioin........somehow, she got pregnant and miscarried while I was back in the USA...

I am going on cycle for about 26 weeks....I am going to use low doses though.,..always have...might up from prior doses used...Dont know yet

[hitch]

well im only 2 weeks into my new 26 week cycle and for the first 12 weeks or maybe more im using 2grams off test a week.
from my post before we can see that i need to increse my EFA intake to get the most from " bulking dose ".

i honestly dont like short cycles because it is muscle gained then pct and most weight is then lost.
i might be controversial in saying this but i look at steroids the same i look at hgh.
we all know for hgh to promote pure lean muscle gains that we will keep we need to use it for a year minimum.
so ok you ask well if hgh promotes new muscle fibles that dont already exsisit and steroids only increase cell volume and rebuild muscle fibres then how hitch does that appear the same as steroids.
well in my view and also anoniymiser states that there is no yo yo effect on a longer AAS cycle compared to a 10 week cycle. so the body gets use to having the extra muscle over the longer period off time and therefore we get to keep the gains from a 1 year cycle.

i also find that around 1 week before we take r last steroid injection before pct time , that igf-1 is super for keeping even more off those muscles we gained on the cycle.
igf-1 is good for recovery in a pct sense.

maybe my views here are maybe a bit strange but its what i have found to work for me from the 1 year cycles.

[longhorn71]

While this study could be somewhat promising, here in lies the problem: I don't think anyone here knows what the exact "contraceptive dose" is of any AAS in a human. There are far too many variables to knock this down.

Also, the test rats were only dosed for 8 months and we don't know what would have happened at say 10 or 12 months. It would have been nice if they would have had more test groups at those time points and beyond.

Also, as the administrator pointed out, this ingnored effects on other bodily functions such as the thyroid which I don't cross lightly.